Research Article
FAS and FASL Gene Polymorphisms Are Not Associated with Hepatitis B Virus Infection Based on a Case-Control Study in a Brazilian Population
Table 1
Comparison of genotype frequencies of the FAS and FASL polymorphisms among the HBV patients and healthy controls.
| | Genotype profile | HBV patients () n (%) | Healthy controls () n (%) | Adjusted OR* | 95% CI | P value† |
| | FAS-670 A>G | | | | | | | AA | 25 (21.55) | 51 (21.70) | | | | | AG | 55 (47.41) | 116 (49.36) | | | | | GG | 36 (31.04) | 68 (28.94) | | | | | AG + GG | 91 (78.45) | 184 (78.30) | 1.0427 | 0.60–1.81 | 0.9154 | | FAS-1377 G>A | | | | | | | GG | 94 (81.04) | 185 (78.73) | | | | | GA | 20 (17.24) | 44 (18.72) | | | | | AA | 02 (01.72) | 06 (02.55) | | | | | GA + AA | 22 (18.96) | 50 (21.27) | 0.8623 | 0.49–1.53 | 0.8283‡ | | Ivs2ntFASLG-124 A>G | | | | | | | AA | 100 (86.21) | 198 (84.26) | | | | | AG | 15 (12.93) | 35 (14.89) | | | | | GG | 01 (00.86) | 02 (00.85) | | | | | AG + GG | 16 (13.79) | 37 (15.74) | 0.8724 | 0.45–1.68 | 0.8936‡ | | Ivs3ntFASLG-169 T>ΔT | | | | | | | TT | 87 (75.00) | 177 (75.32) | | | | | T/ΔT | 25 (21.55) | 56 (23.83) | | | | | ΔT/ΔT | 04 (03.45) | 02 (00.85) | | | | | T/ΔT + ΔT/ΔT | 29 (25.00) | 58 (24.68) | 0.9987 | 0.59–1.69 | 0.2403‡ | | FASLG-844 C>T | | | | | | | CC | 51 (43.96) | 99 (42.13) | | | | | CT | 47 (40.52) | 112 (47.66) | | | | | TT | 18 (15.52) | 24 (10.21) | | | | | CT + TT | 65 (56.04) | 136 (57.87) | 0.9527 | 0.60–1.52 | 0.2513 |
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Multiple logistic regression; †Chi-squared test; ‡G test.
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