RNA-Seq Data Mining: Downregulation of NeuroD6 Serves as a Possible Biomarker for Alzheimer’s Disease Brains
Table 2
The set of 15 genes DEGs downregulated in cortical neurons of the superior frontal gyrus of AD identified by microarray data analysis of GSE5281 corresponding to RNA-Seq data analysis of SRA060752.
Solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
0.156759363
728192
LINC00460
Long intergenic non-protein-coding RNA 460
0.171656016
891
CCNB1
Cyclin B1
0.182817517
523
ATP6V1A
ATPase, H+ transporting, lysosomal 70 kDa, V1 subunit A
0.190442377
7991
TUSC3
Tumor suppressor candidate 3
0.200399391
1741
DLG3
Discs, large homolog 3 (Drosophila)
0.222930685
63974
NeuroD6
Neurogenic differentiation 6
0.237572737
3382
ICA1
Islet cell autoantigen 1, 69 kDa
0.249762845
844
CASQ1
Calsequestrin 1 (fast-twitch, skeletal muscle)
0.271852315
9577
BRE
Brain and reproductive organ-expressed (TNFRSF1A modulator)
0.306075086
84900
RNFT2
Ring finger protein, transmembrane 2
0.306171729
9515
STXBP5L
Syntaxin binding protein 5-like
0.360338998
The set of 215 DEGs in LCM-captured frontal cortex neurons of AD satisfying value <0.0001 by two-tailed -test and fold change greater than 2 or smaller than 0.5 were extracted by microarray data analysis of GSE5281. Among them, the set of 15 genes corresponding to the core set of 522 DEGs identified by RNA-Seq data analysis of SRA060572 are listed with Entrez Gene ID, gene symbol, gene name, fold change, and value. NeuroD6 is italicized. The complete set of 215 DEGs are shown in Supplementary Table 3.