Immunohistochemical Correlation of Matrix Metalloproteinase-2 and Tissue Inhibitors of Metalloproteinase-2 in Tobacco Associated Epithelial Dysplasia

Table 2

Expression of MMP-2 and TIMP-2 in cells of basal and parabasal layers and fibroblasts in all the grades of dysplasia.

Cells	Dysplasia	MMP-2 score			Total	Chi-square	𝑃 value*	TIMP-2 score			Total	Chi-square	𝑃 value*
		−	+	++				−	+	++
Basal	Normal	10	0	0	10	35.833	<0.001	10	0	0	10	39.461	<0.001
	Mild	5	5	0	10			1	9	0	10
	Moderate	0	7	3	10			0	8	2	10
	Severe	0	4	6	10			0	7	3	10
	Total	15	16	9	40			11	24	5	40
Parabasal	Normal	10	0	0	10	33.461	<0.001	10	0	0	10	32.923	<0.001
	Mild	5	5	0	10			3	7	0	10
	Moderate	1	9	0	10			0	10	0	10
	Count	1	5	4	10			0	9	1	10
	Total	17	19	4	40			13	26	1	40
Fibroblast	Normal	10	0	0	10	46.582	<0.001	10	0	0	10	38.156	<0.001
	Mild	1	9	0	10			1	9	0	10
	Moderate	0	9	1	10			0	10	0	10
	Severe	0	5	5	10			0	9	1	10
	Total	11	23	6	40			11	28	1	40

MMP-2: matrix metalloproteinase-2; TIMP-2: tissue inhibitor of metalloproteinase-2.
*Kruskal-Wallis test.