Immunohistochemical Correlation of Matrix Metalloproteinase-2 and Tissue Inhibitors of Metalloproteinase-2 in Tobacco Associated Epithelial Dysplasia

Table 3

The mean rank of MMP-2 and TIMP-2 in different grades of dysplasia.

Cells	Markers	Dysplasia	Cases	Mean rank	Chi-square	𝑃 value*
Basal cells	MMP-2	Normal	10	8.00	27.462	<0.001
		Mild	10	15.40
		Moderate	10	26.30
		Severe	10	32.30
	TIMP-2	Normal	10	6.00	26.125	<0.001
		Mild	10	19.15
		Moderate	10	26.05
		Severe	10	30.80
Parabasal cells	MMP-2	Normal	10	9.00	22.065	<0.001
		Mild	10	17.10
		Moderate	10	24.55
		Severe	10	31.35
	TIMP-2	Normal	10	7.00	25.495	<0.001
		Mild	10	17.50
		Moderate	10	26.70
		Severe	10	30.80
Fibroblasts	MMP-2	Normal	10	6.00	26.599	<0.001
		Mild	10	19.25
		Moderate	10	25.25
		Severe	10	31.50
	TIMP-2	Normal	10	6.00	26.660	<0.001
		Mild	10	19.10
		Moderate	10	25.50
		Severe	10	31.40

MMP-2: matrix metalloproteinase-2; TIMP-2: tissue inhibitor of metalloproteinase-2.
*Kruskal-Wallis test.