Review Article

MicroRNAs-Role in Lung Cancer

Figure 1

miRNA biogenesis and mechanism of action. miRNAs are transcribed by polymerase II into primary transcripts (pri-miRNAs). Pri-miRNAs are cleaved by the Drosha resulting in the formation of a hairpin precursor (pre-miRNAs). Exportin 5 transports pre-miRNAs to the cytoplasm, where Dicer processes them into miRNAs duplexes. One strand of the duplex (mature miRNA) is incorporated into the RNA-induced silencing complex (RISC) and binds to 3′-UTR of target mRNA resulting in either its degradation or translational repression.
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