Prediabetes Is Associated with HNF-4α P2 Promoter Polymorphism rs1884613: A Case-Control Study in Han Chinese Population and an Updated Meta-Analysis

Table 2

Comparison of genotypic and allelic distribution of rs1884613 in the (HNF)-4α gene among subjects with type 2 diabetes, Prediabetes, and healthy controls.

HNF4A; rs1884613	CC	CG	GG	C	G	Additive model		Dominant model		Recessive model		HWE
						OR (95% CI)		OR (95% CI)		OR (95% CI)
Controls	171	288	94	630	476							0.14
Prediabetes	128	224	117	480	458	1.40 (1.16–1.68)	0.0001^a	1.47 (1.10–1.96)	0.008^a	1.68 (1.22–2.32)	0.001^a
Type 2 diabetes	148	260	79	556	418	1.09 (0.82–1.32)	0.33	1.21 (0.92–1.60)	0.16	1.00 (0.70–1.41)	0.99
Female	CC	CG	GG	C	G
Controls	92	145	43	329	231							0.25
Prediabetes	71	108	60	250	228	1.48 (1.14–1.92)	0.003^a	1.55 (1.04–2.30)	0.02	1.91 (1.20–3.04)	0.006^a
Type 2 diabetes	79	136	30	294	196	1.08 (0.54–1.43)	0.54	1.31 (0.89–1.94)	0.16	0.81 (0.47–1.38)	0.44
Male	CC	CG	GG	C	G
Controls	79	143	51	301	245							0.33
Prediabetes	57	116	57	230	230	1.33 (1.02–1.73)	0.035	1.41 (0.93–2.15)	0.09	1.50 (0.96–2.34)	0.07
Type 2 diabetes	69	124	49	262	222	1.11 (0.85–1.44)	0.42	1.14 (0.77–1.71)	0.49	1.15 (0.73–1.82)	0.54

Significant results.
All of the ORs (95% CIs) and values were adjusted for age and BMI.