Prediabetes Is Associated with HNF-4α P2 Promoter Polymorphism rs1884613: A Case-Control Study in Han Chinese Population and an Updated Meta-Analysis
Table 2
Comparison of genotypic and allelic distribution of rs1884613 in the (HNF)-4α gene among subjects with type 2 diabetes, Prediabetes, and healthy controls.
HNF4A rs1884613
CC
CG
GG
C
G
Additive model
Dominant model
Recessive model
HWE
OR (95% CI)
OR (95% CI)
OR (95% CI)
Controls
171
288
94
630
476
0.14
Prediabetes
128
224
117
480
458
1.40 (1.16–1.68)
0.0001a
1.47 (1.10–1.96)
0.008a
1.68 (1.22–2.32)
0.001a
Type 2 diabetes
148
260
79
556
418
1.09 (0.82–1.32)
0.33
1.21 (0.92–1.60)
0.16
1.00 (0.70–1.41)
0.99
Female
CC
CG
GG
C
G
Controls
92
145
43
329
231
0.25
Prediabetes
71
108
60
250
228
1.48 (1.14–1.92)
0.003a
1.55 (1.04–2.30)
0.02
1.91 (1.20–3.04)
0.006a
Type 2 diabetes
79
136
30
294
196
1.08 (0.54–1.43)
0.54
1.31 (0.89–1.94)
0.16
0.81 (0.47–1.38)
0.44
Male
CC
CG
GG
C
G
Controls
79
143
51
301
245
0.33
Prediabetes
57
116
57
230
230
1.33 (1.02–1.73)
0.035
1.41 (0.93–2.15)
0.09
1.50 (0.96–2.34)
0.07
Type 2 diabetes
69
124
49
262
222
1.11 (0.85–1.44)
0.42
1.14 (0.77–1.71)
0.49
1.15 (0.73–1.82)
0.54
Significant results. All of the ORs (95% CIs) and values were adjusted for age and BMI.