A New Susceptibility Locus for Myocardial Infarction, Hypertension, Type 2 Diabetes Mellitus, and Dyslipidemia on Chromosome 12q24
Table 2
Association of hepatic nuclear factor 1 alpha with cardiovascular disease traits.
S.E.
Wald
value
Exp ()
95% C.I. for Exp ()
Lower
Upper
Myocardial infarction
rs2259820_CC
0.178
0.087
4.20
0.041
1.19
1.01
1.42
rs2464196_TT
0.171
0.086
4.01
0.045
1.19
1.00
1.40
rs2259816_T
0.123
0.057
4.67
0.031
1.13
1.01
1.26
Type 2 diabetes mellitus
rs2259820_T
0.129
0.051
6.40
0.011*
1.14
1.03
1.26
rs2259820_CT+TT
0.178
0.085
4.39
0.036
1.20
1.01
1.41
rs2464196_C
0.114
0.051
5.06
0.024
1.12
1.02
1.24
rs1169310_G
−0.104
0.051
4.17
0.041
0.90
0.82
1.00
Hypertension
rs2393791_T
0.127
0.059
4.58
0.032
1.14
1.01
1.28
rs7310409_G
0.148
0.059
6.16
0.013*
1.16
1.03
1.30
rs2259820_T
−0.149
0.059
6.46
0.011*
0.86
0.77
0.97
rs2464196_AG+GG
0.223
0.088
6.39
0.012*
1.25
1.05
1.49
Hypertriglyceridemia
rs2393791_T
0.129
0.054
5.59
0.018*
1.14
1.02
1.27
rs7310409_G
0.117
0.054
4.64
0.031
1.12
1.01
1.25
rs2259820_C
−0.130
0.054
5.82
0.016*
0.88
0.79
0.98
rs2464196_T
−0.108
0.054
4.04
0.044
0.90
0.81
1.00
rs2259816_T
−0.117
0.055
4.52
0.034
0.90
0.80
0.99
rs1169310_G
0.140
0.054
6.71
0.010*
1.15
1.04
1.28
rs1169313_(CT+TT)
0.215
0.080
7.14
0.008*
1.24
1.06
1.45
High low-density lipoprotein-cholesterol level
rs2259820_T
0.203
0.070
8.44
0.004**
1.23
1.07
1.41
rs2464196_T
0.198
0.069
8.16
0.004**
1.22
1.06
1.39
rs2259816_T
0.164
0.072
5.19
0.023
1.18
1.02
1.36
rs1169310_G
−0.175
0.071
6.13
0.013*
0.84
0.73
0.96
rs1169313_T
−0.160
0.071
5.10
0.024
0.85
0.74
0.98
The table lists the variants associated with myocardial infarction (MI; 3044 cases versus 1587 controls), type 2 diabetes mellitus (2550 versus 2081), hypertension (3528 versus 1103), hypertriglyceridemia (1160 versus 3156), and high low-density lipoprotein-cholesterol level (631 versus 3681) among the 4631 studied individuals before and following adjustments for the influences of other risks factors, following Bonferroni correction and adjustment confounding effects of coexisting diseases and covariates (see Supplementary Data). : beta coefficient; C.I.: confidence interval; Exp: exponential; values: adjusted significance value after adjustments for confounders. ; .
