Annexin A2: Its Molecular Regulation and Cellular Expression in Cancer Development

Table 2

Summary of the effects of ANXA2 on cancer cells.

Cancer	Description	Reference
Breast cancer	The siRNA targeting ANXA2 of MDA-MB-435s cells downregulates the levels of plasmin, S100A10, and c-Myc and thus retards breast cancer proliferation and invasion	[55]
Colorectal carcinoma	ANXA2 downregulation is not due to proteasome activation and seems to be related to the butyrate-induced cell proliferation arrest	[76]
Colorectal carcinoma	ANXA2 can mediate growth stimulatory effects of autocrine and exogenous gastrin and PG peptides on intestinal epithelial and colon cancer cells	[77]
NSCLC	Knockdown of ANXA2 upregulates p53 and causes cell cycle arrest so efficiently as to retard cell proliferation	[86]
Pancreatic cancer	Increased expression of ANXA2 colocalizes with cells that express PCNA	[69]
Prostate cancer	Aberrant accumulation of nuclear ANXA2 retards proliferation of LNCaP cells	[99]
Prostate cancer	ANXA2 may facilitate the growth of prostate cancer in vitro and in vivo by the MAPK pathway	[100]
Prostate cancer	Intracellular ANXA2 contributes to secretion of IL-6 in prostate cancer, and this effect requires the C-terminus of ANXA2	[24]