Comparative Plasma Protein Profiling of Hemoglobin H Disease

Figure 1

Differential expression of plasma proteins comparing between normal control and HbH disease. Three representative 2D gels of normal control, HbH, and HbH-CS plasma proteins are shown. The protein spots were analyzed using Image Master 2D-Platinum version.5 software (Amersham Biosciences). Comparing between normal control and HbH patients, a total of 17 significantly different protein spots with 11 downregulated proteins (spot numbers H01, H02, H03, H07, H08, H09, H10, H11, H12, H13, and H14) and 6 upregulated proteins (spot number H04, H05, H06, H15, H16, and H17) were detected. Ten differential plasma protein spots were detected when compared between HbH and HbH-CS including 8 downregulated (spot number H03, H07, H08, H09, H11, H12, H13, and H14) and 2 upregulated (spot number H16 and H17).