Comparative Plasma Protein Profiling of Hemoglobin H Disease

Table 1

Clinical parameters of 12 normal controls, 12 HbH, and 10 HbH-CS patients.

Parameters	Normal subjects (𝑛=12)	Patients (𝑛=22)	HbH (𝑛=12)	HbH-CS (𝑛=10)
Gender (male/female)	5/7	9/13	5/7	4/6
Hb (g/dL)*	13.28 ± 0.97	8.74 ± 1.03	9.32 ± 1.08	8.17 ± 0.59
Hct (%)*	39.8 ± 3.59	34.85 ± 4.08	36.43 ± 3.58	33.27 ± 4.21
WBC (×10^3/mL)	7.02 ± 1.03	6.19 ± 1.78	6.43 ± 2.22	4.42 ± 1.37
RBC (×10^6/mL)	4.53 ± 0.40	4.74 ± 0.98	5.02 ± 1.11	5.95 ± 0.79
MCV (fL)*	87.78 ± 2.42	74.02 ± 5.46	73.53 ± 6.62	74.50 ± 5.75
MCH (pg)*	29.37 ± 0.89	18.06 ± 1.78	18.03 ± 1.39	18.08 ± 2.24
MCHC (g/dL)*	33.43 ± 0.75	24.41 ± 2.00	24.05 ± 1.30	24.32 ± 2.67

Data are presented as mean ± standard deviation (SD). Hb: hemoglobin, Hct: hematocrit, WBC: white blood cells, RBC: red blood cells, MCV: mean corpuscular volume, MCH: mean corpuscular hemoglobin, and MCHC: mean corpuscular hemoglobin concentration.
^∗𝑃 value <0.05 compared between normal control and HbH disease.