Comparative Plasma Protein Profiling of Hemoglobin H Disease

Table 3

List of 10 differential spots representing 7 plasma proteins compared between HbH and HbH-CS.

Number	Name of protein	MW*	pI**	MOWSE score	Sequence coverage (%)	Intensity ratio of HbH/HbH-CS	𝑃 value	Tissue specificity	Functions
H03	Complement C3	79294	6.02	272	11	2.96	0.077	Liver	Phagocytosis, inflammatory responses, activation cell damage
H11	Haptoglobin	45861	6.13	172	13	4.81	0.021	Liver	Hb-scavenging proteins
H12	Haptoglobin	45861	6.13	172	13	3.47	0.016
H13	Haptoglobin	45861	6.13	102	13	2.88	0.049
H14	Transthyretin	15991	5.52	325	34	5.48	0.002	Liver	Thyroxin-binding prealbumin, redox reaction
H08	Actin	42052	5.29	141	29	3.21	0.043	Cell membrane	Red-cell skeleton membrane protein
H09	Haptoglobin-related protein	71317	5.92	403	40	2.07	0.028	Liver	Liver damage
H07	Serum paraoxonase	39877	5.08	72	17	2.54	0.047	Liver	Antioxidant, detoxification of organophosphates
H-16	Serum albumin	71317	5.92	363	20	0.57	0.021	Liver	Regulation of the colloidal osmotic pressure of blood
H-17	Serum albumin	71317	5.92	180	17	0.49	0.039

∗∗pI: isoelectric point and *Mw: molecular weight.