Research Article

The Association between Bile Salt Export Pump Single-Nucleotide Polymorphisms and Primary Biliary Cirrhosis Susceptibility and Ursodeoxycholic Acid Response

Table 5

The association between BSEP SNPs and UDCA response.

SNPUDCA CR (%)UDCA NR (%)Adjusted* OR (95% CI) value

rs52304393
 CC + CT28 (0.44)13 (0.41)1.34 (0.21–0.99)0.58
 TT36 (0.56)19 (0.59)1.00
rs473351
 AA + AG14 (0.22)6 (0.20)1.63 (1.01–4.87)0.90
 GG50 (0.78)26 (0.80)1.00
rs860510
 TT + TG40 (0.62)18 (0.57)1.32 (1.03–2.38)0.22
 GG24 (0.38)14 (0.43)1.00
rs2287618
 AA + AG38 (0.60)14 (0.43)0.32 (0.25–0.65)0.01
 GG26 (0.40)18 (0.57)1.00

By age and sex adjustment and analyzed by logistic regression analyses.