Clinical Study
Neutrophil-to-Lymphocyte Ratio as a Predictor of Response to Peginterferon plus Ribavirin Therapy for Chronic Hepatitis C
Table 2
Factors associated with rapid virological response and sustained virological response to peginterferon plus ribavirin in chronic hepatitis C patients.
| | | RVR () | Non-RVR () | value | SVR () | Non-SVR () | value |
| | Age (mean ± SD) (yr) | 53.7 ± 11.5 | 55.8 ± 10.0 | 0.032 | 53.6 ± 11.1 | 56.5 ± 10.8 | 0.006 | | Gender (male/female) | 237/199 | 79/87 | 0.082 | 243/215 | 73/71 | 0.634 | | rs12979860 (CC/CT or TT) | 312/34 | 110/33 | <0.001 | 326/40 | 96/27 | 0.004 | | Cirrhosis (%) | 57 (13%) | 34 (20%) | <0.001 | 51 (11%) | 40 (28%) | <0.001 | | DM (%) | 76 (17%) | 27 (16%) | 0.418 | 71 (16%) | 32 (22%) | 0.075 | | BMI (kg/m2) | 24.6 ± 3.7 | 25.1 ± 3.9 | 0.161 | 24.6 ± 3.6 | 25.1 ± 4.1 | 0.161 | | Log HCV-RNA (IU/mL) | 5.2 ± 1.0 | 6.1 ± 0.6 | <0.001 | 5.3 ± 1.0 | 5.9 ± 0.7 | <0.001 | | Genotype 1/non-1 | 126/296 | 137/25 | <0.001 | 177/269 | 86/52 | <0.001 | | RVR (%) | — | — | — | 370 (81%) | 66 (46%) | <0.001 | | WBC (103/μL) | 5.8 ± 1.6 | 5.8 ± 1.9 | 0.597 | 5.8 ± 1.7 | 6.0 ± 4.2 | 0.482 | | N-L ratio | 1.55 ± 0.82 | 1.74 ± 1.05 | 0.032 | 1.55 ± 0.75 | 1.78 ± 1.24 | 0.034 | | Platelet (104/μL) | 17.7 ± 5.7 | 17.2 ± 6.4 | 0.424 | 17.9 ± 5.6 | 16.6 ± 6.8 | 0.037 |
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RVR: rapid virological response; DM: diabetes mellitus; BMI: body mass index; HCV: hepatitis C virus; RVR: rapid virological response; N-L ratio: neutrophil-lymphocyte ratio.
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