Neutrophil-to-Lymphocyte Ratio as a Predictor of Response to Peginterferon plus Ribavirin Therapy for Chronic Hepatitis C

Table 3

Comparison of clinical and laboratory characteristics between high and low neutrophil-lymphocyte ratio of chronic hepatitis C patients.

	High N-L ratio ≥ 1.42; ()	Low N-L ratio < 1.42; ()	value
Age (mean ± SD) (yr)	53.5 ± 11.8	55.0 ± 10.4	0.101
Gender (male/female)	169/137	147/149	0.192
rs12979860 (CC/CT or TT)	218/32	96/27	0.600
Cirrhosis (%)	53 (17%)	38 (13%)	0.139
DM (%)	61 (20%)	42 (14%)	0.039
BMI (kg/m^2)	24.6 ± 4.0	24.9 ± 3.4	0.299
Log HCV-RNA (IU/mL)	5.6 ± 0.9	5.3 ± 1.0	0.002
Genotype 1/non-1	140/158	123/163	0.360
WBC (10^3/μL)	6.2 ± 3.2	5.4 ± 1.5	<0.001
Hemoglobin (g/dL)	14.1 ± 1.7	14.1 ± 1.4	0.846
Platelet (10^4/μL)	17.8 ± 6.1	17.3 ± 5.7	0.307

As determined by ROC curve for best cut-off for predicting SVR.
N-L ratio: neutrophil-lymphocyte ratio; DM: diabetes mellitus; BMI: body mass index; RVR: rapid virological response; WBC: white cell count.