Recipients with In Utero Induction of Tolerance Upregulated MHC Class I in the Engrafted Donor Skin
Figure 1
Donor-specific skin tolerance. Mixed chimerism was established in FVB/N mice through in utero transplantation of C57BL/6 marrows. A representative FVB/N mixed chimera was rendered tolerant to C57BL/6 donor skin (a). The donor-specific (black hair) and syngeneic (arrow) skins had been accepted for more than 4 months after their placement. The rejection of third-party C3H skin caused an area of scarring (arrowhead). Hematoxylin-eosin staining did not reveal inflammatory cell infiltration in the engrafted C57BL/6 donor skin (b), which contained melanin pigments within keratinocytes of basal epidermis (arrowhead) and in the dermis (arrow).
