Diagnostic and Prognostic Role of Preoperative Circulating CA 15-3, CA 125, and Beta-2 Microglobulin in Renal Cell Carcinoma

Table 1

Patients clinical and pathological characteristics.

Characteristic	RCC patients (𝑛=332)	Healthy subjects (𝑛=113)	𝑃 value
Age (years)
Median	63	61
Range	20–85	22–84
Gender
M	230 (69.3%)	81 (71.6%)
F	102 (30.7%)	32 (28.4%)
Type of nephrectomy
Radical	167 (50.3%)
Partial	165 (49.7%)
Tumor size (cm)
Median	4.5
Range	0.4–24
Pathological stage
pT1a	141 (42.5%)
pT1b	84 (25.3%)
pT2	28 (8.4%)
pT3	79 (23.8%)
LN metastases	21 (6.3%)
Visceral metastases	27 (8.1%)
Fuhrman grade
G1-2	212 (63.8%)
G3-4	120 (36.2%)
Histological subtype
Clear cell	246 (74.1%)
Papillary	32 (9.6%)
Chromophobe	54 (16.3%)
CA 15-3 (U/mL)
Median	21.74	16.02	<0.0001
95% CI	20.05–22.61	14.44–16.56
CA 125 (U/mL)
Median	10.56	7.98	<0.0001
95% CI	9.61–12.00	7.03–9.48
β-2 m (mg/L)
Median	2.00	1.70	<0.0001
95% CI	1.90–2.10	1.50–1.72