Research Article
Identification of Differentially Expressed Serum Proteins in Infectious Purpura Fulminans
Table 2
List of 27 potentially purpura fulminans-associated proteins (SpCPF/N ≥ 2 or ≤0.5) identified by HPLC-Chip/MS across the two biological groups.
| Gene symbol | Protein name | Protein function | % AA coverage | Distinct peptides | SpCPF/N | Up-/downregulation |
| AGT | Angiotensinogen | Maintain blood pressure | 18 | 7 | 10.32 | Up | ALDOB | Fructose-bisphosphate aldolase B | Glycolysis | 13 | 4 | 38.69 | Up | APCS | Serum amyloid P-component | Amyloidosis | 16 | 3 | 2.06 | Up | APOC3 | Apolipoprotein C-III | Lipoprotein metabolism | 27 | 2 | 2.06 | Up | APOD | Apolipoprotein D | Lipoprotein metabolism | 25 | 4 | 2.32 | Up | C1QC | Complement C1q subcomponent subunit C | Complement system | 17 | 3 | 3.1 | Up | C7 | Complement component 7 | Complement system | 6 | 3 | 0.04 | Down | C8G | Complement component 8 gamma | Complement system | 23 | 3 | 0.04 | Down | CFI | Complement factor I | Complement system | 6 | 3 | 4.64 | Up | CPN2 | Carboxypeptidase N subunit 2 | | 5 | 2 | 6.19 | Up | F5 | Coagulation factor V | Coagulation cascade | 2 | 4 | 0.05 | Down | FGA | Fibrinogen alpha chain | Coagulation cascade | 4 | 3 | 67.7 | Up | GC | Vitamin D binding protein | Bind vitamin D | 25 | 11 | 2.58 | Up | GSN | Gelsolin | Assembly and disassembly of actin filaments | 16 | 8 | 0.23 | Down | IGFALS | Insulin-like growth factor binding protein complex acid labile chain | Bind insulin-like growth factors | 7 | 3 | 3.35 | Up | LBP | Lipopolysaccharide-binding protein | Immune response | 8 | 3 | 17.03 | Up | LRG1 | Leucine-rich alpha-2-glycoprotein 1 | Signal transduction | 20 | 6 | 2.63 | Up | LUM | Lumican | Collagen fibril organization | 5 | 2 | 3.16 | Up | ORM2 | Alpha-1-acid glycoprotein 2 | Acute phase response | 21 | 4 | 3.41 | Up | PGLYRP2 | N-acetylmuramoyl-L-alanine amidase | Digest peptidoglycan | 4 | 2 | 0.02 | Down | PKM2 | Pyruvate kinase isozymes | Glycolysis | 4 | 2 | 38.69 | Up | SAA | Serum amyloid A protein | Acute phase protein | 39 | 3 | 58.03 | Up | SERPINA1 | Alpha-1-antitrypsin | Serine protease inhibitors | 20 | 8 | 145.08 | Up | SERPINA6 | Corticosteroid-binding globulin | Transport glucocorticoids | 6 | 2 | 3.16 | Up | SERPINA7 | Thyroxine-binding globulin | Transport thyroid hormone | 4 | 2 | 0.02 | Down | SERPINF1 | Pigment epithelium derived factor | Inhibit angiogenesis | 5 | 2 | 29.02 | Up | SERPINF2 | Alpha-2 antiplasmin | Coagulation cascade | 8 | 3 | 0.39 | Down |
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