STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis
Table 5
Correlations between STAT4 SNPs and autoantibody positivity.
db SNP
Allele
ANA+ (%)
ANA− (%)
P
OR
95% CI
AMA+ (%)
AMA− (%)
P
Cenp+ (%)
Cenp− (%)
P
gp210+ (%)
gp210− (%)
P
minor/major
()
()
()
()
()
()
()
()
rs10168266
A/G
35.6
33.1
0.50
34.2
42.3
0.24
36.1
35.3
0.83
35.0
32.5
0.58
rs7594501
A/G
11.5
14.9
0.18
12.9
7.7
0.27
13.0
12.6
0.87
11.9
12.8
0.77
rs16833239
T/C
11.6
15.3
0.15
13.1
7.7
0.26
12.6
13.4
0.77
13.1
13.1
0.98
rs11889341
T/C
41.3
34.7
0.076
38.8
46.2
0.29
59.7
59.7
1.00
39.4
37.2
0.64
rs7574865
T/G
44.5
36.7
0.040
1.38
1.01–1.88
41.6
48.1
0.36
42.4
43.6
0.76
43.1
38.3
0.30
rs8179673
G/A
44.8
36.7
0.032
1.40
1.03–1.91
41.9
48.1
0.38
42.9
43.8
0.81
43.1
38.6
0.33
rs10181656
G/C
46.1
37.9
0.031
1.40
1.03–1.91
43.1
50.0
0.33
45.0
44.4
0.90
43.1
38.6
0.33
rs6752770
G/A
15.4
14.1
0.63
15.3
11.5
0.47
13.4
14.7
0.64
15.0
15.8
0.81
STAT4: signal transducer activator transcription 4; PBC: primary biliary cirrhosis; SNP: single nucleotide polymorphism; OR: odds ratio; CI: confidence interval; AMA: anti-mitochondrial antibody; ANA: anti-nuclear antibody; Cenp: anti-centromere antibody; gp210: gp210 antibody; : values for indicate two times the number of individuals since each person carries two haplotypes.
