STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis
Table 6
Correlations between STAT4 haplotypes and autoantibody positivity.
Block
Haplotype
SNPs
ANA+ (%)
ANA− (%)
P
OR
95% CI
AM+ (%)
AMA− (%)
P
Cenp+ (%)
Cenp− (%)
P
gp210+ (%)
gp210− (%)
P
()
()
()
()
()
()
()
A
rs7594501
rs16833239
rs11889341
1
G
C
C
46.7
49.6
0.45
47.7
46.2
0.83
46.6
46.1
0.89
47.5
49.2
0.73
2
G
C
T
41.3
34.7
0.076
38.8
46.2
0.29
40.3
40.3
1.00
39.4
37.2
0.64
3
A
T
C
11.1
14.5
0.17
12.5
7.7
0.31
12.6
12.3
0.92
11.9
12.2
0.91
B
rs7574865
rs8179673
rs10181656
0.0
4
G
A
C
53.7
61.7
0.035
0.72
0.53–0.98
56.8
48.1
0.22
54.6
55.3
0.85
56.9
61.4
0.33
5
T
G
G
44.3
36.3
0.035
1.40
1.02–1.90
41.5
46.2
0.51
42.0
43.4
0.72
43.1
38.3
0.30
6
G
A
G
1.5
1.6
0.88
1.4
3.8
0.16
2.5
0.8
0.066
0.0
0.0
—
STAT4: signal transducer activator transcription 4; PBC: primary biliary cirrhosis; SNP: single nucleotide polymorphism; OR: odds ratio; CI: confidence interval; AMA: anti-mitochondrial antibody; ANA: anti-nuclear antibody; Cenp: anti-centromere antibody; gp210: gp210 antibody; : values for indicate two times the number of individuals since each person carries two haplotypes.
