Clinical Study

A Comparison of KL-6 and Clara Cell Protein as Markers for Predicting Bronchopulmonary Dysplasia in Preterm Infants

Table 1

Comparison of demographic and clinical characteristics between infants with and without BPD.

BPDWithout BPDP value

Number of patients2449
Birth weight, g1124.6 ± 216.81311.8 ± 115.6<0.0001

Gestational age, weeks29.2 ± 1.731.2 ± 1.00.07
Male15 (62.5%)22 (44.9%)0.16

Apgar score at 1 min5.5 3.5–77 5–70.14
Apgar score at 5 min6 5–87 7-80.10

Apgar score at 10 min7 7-88 [8-80.07
Vaginal delivery7 (29.2%)9 (18.4%)0.3

Prenatal steroids23 (95.8%)44 (89.8%)0.39
Maternal pregnancy-induced hypertension7 (29.2%)18 (36.7%)0.52

Maternal diabetes2 (8.3%)1 (2.0%)0.24
Maternal infection2 (8.3%)4 (8.2%)0.98

Premature rupture of membranes11 (45.8%)13 (26.5%)0.1
Cord blood pH7.30 ± 0.087.30 ± 0.081.0

Ureaplasma urealyticum positive in urine3 (12.5%)12 (13.3%)0.56
Surfactant use23 (95.8%)31 (34.4%)0.03

Mechanical ventilation ≥1 week11 (45.8%)4 (8.2%)0.003
Pneumonia4 (16.7%)3 (6.1%)0.17

Sepsis18 (75.0%)22 (44.9%)0.02
 Sepsis occurred within 15 days after birth16 (66.7%)14 (28.6%)0.003
 Sepsis occurred after 15 days after birth2 (8.3%)8 (16.3%)0.36
Patent ductus arteriosus6 (25.0%)4 (8.2%)0.06

Length of stay, d49.9 ± 11.240.3 ± 6.60.0001
Patients discharged alive20 (83.3%)49 (100.0%)0.04

Values are expressed as median [range] or number of individuals (percentage).