Methylation of DLEC1 Promoter Is a Predictor for Recurrence in Chinese Patients with Gastric Cancer

Table 3

Multivariate analysis of recurrence-free survival in gastric cancer according to clinicopathological variables and DLEC1 methylation.

Clinicopathological variables	HR	95% CI	value
Age (≤65 versus >65)	1.12	0.91–2.04	0.073
Gender (male versus > female)	1.05	0.70–1.21	0.103
Tumor size (<4 versus ≥4)	1.58	1.16–2.26	0.058
Depth of invasion (Tis-1 versus T2-4)	3.81	1.68–6.85	0.008
Lymphatic invasion (+ versus −)	4.54	2.06–7.36	0.001
Venous invasion (+ versus −)	2.86	1.43–5.01	0.017
TNM staging (0-I versus II–IV)	2.32	1.26–4.83	0.036
Lauren classification (intestinal versus diffuse type)	3.66	1.37–8.94	0.009
Lymph node metastasis (+ versus −)	3.92	1.78–7.15	0.002
DLEC1 methylation (>35.10 versus ≤35.10)	2.43	1.38–5.07	0.025