Impact of Serum Biomarkers and Clinical Factors on Intensive Care Unit Mortality and 6-Month Outcome in Relatively Healthy Patients with Severe Pneumonia and Acute Respiratory Distress Syndrome
Table 4
Serum biomarker characteristics between 6-month life-independent and life-dependent patients.
6-month life independence (n = 25)
6-month life dependence (n = 10)
P
CRP (mg/L)
Day 1
174.40 ± 93.51
205.24 ± 151.19
0.468
Day 3
98.52 ± 70.53
97.91 ± 78.28
0.982
Day 3 : day 1
1.09 ± 2.53
0.51 ± 0.20
0.480
PCT (ng/mL)
Day 1
8.15 ± 9.47
8.41 ± 7.40
0.939
Day 3
3.66 ± 3.34
11.32 ± 22.53
0.101
Day 3 : day 1
3.35 ± 11.57
1.97 ± 4.44
0.717
D-dimer (mg/L)
Day 1
4.12 ± 2.18
4.06 ± 1.19
0.928
Day 3
4.57 ± 4.99
3.06 ± 1.68
0.358
Day 3 : day 1
1.52 ± 2.67
0.78 ± 0.38
0.390
Lactate (mg/dL)
Day 1
20.01 ± 8.37
26.32 ± 13.06
0.090
Day 3
13.40 ± 7.16
19.45 ± 7.84
0.035
Day 3 : Day 1
0.80 ± 0.60
0.84 ± 0.36
0.849
Albumin (g/dL)
Day 1
2.76 ± 0.39
2.18 ± 0.49
0.001
Day 3
2.73 ± 0.47
2.39 ± 0.39
0.051
Day 3 : Day 1
0.99 ± 0.13
1.11 ± 0.15
0.017
HMGB1 (pg/mL)
Day 1
1425.36 ± 578.39
1881.06 ± 731.29
0.049
Day 3
1281.25 ± 492.45
2009.14 ± 754.99
0.002
Day 3 : Day 1
0.95 ± 0.34
1.20 ± 0.50
0.103
IL-8 (pg/mL)
Day 1
55.52 ± 33.40
49.27 ± 53.66
0.678
Day 3
50.80 ± 23.57’
35.63 ± 7.95
0.057
Day 3 : Day 1
1.07 ± 0.58
1.38 ± 1.28
0.317
IL-10 (pg/mL)
Day 1
39.72 ± 32.64
34.88 ± 42.36
0.719
Day 3
43.03 ± 36.08
25.35 ± 26.73
0.171
Day 3 : Day 1
1.18 ± 0.88
1.20 ± 0.82
0.941
Continuous variables were analyzed by Student’s t-test or Mann-Whitney U test, and categorical data by Chi-square test.
bCRP: C-reactive protein; PCT: procalcitonin; HMGB1: high-mobility group protein B1; and IL: interleukin.
cVariables are expressed as mean (standard deviation) and categorical data are expressed as number (percentage).
