Impact of Serum Biomarkers and Clinical Factors on Intensive Care Unit Mortality and 6-Month Outcome in Relatively Healthy Patients with Severe Pneumonia and Acute Respiratory Distress Syndrome
Table 5
Multivariate logistic regression analysis for identification of independent clinical factors and biomarkers of predicting ICU mortality.
Variable
Adjusted odds ratio
95% Confidence interval
P
Clinical factors for predicting ICU mortality
Age
1.506
0.807–2.810
0.198
Initial appropriate antibiotics use
0.032
0.001–0.814
0.037
APACHE II score
Day 1
0.001
<0.001–90.210
0.239
Day 3
1024.53
0.009–1.187
0.244
Day 3 : day 1
8.566
0.003–27664.475
0.602
SOFA score
Day 1
0.032
<0.001–34.761
0.335
Day 3
2.756
0.711–10.687
0.143
SAPS II score
Day 1
2.222
0.111–44.423
0.601
Day 3
0.558
0.030–10.234
0.694
Day 3 : Day 1
0.469
<0.001–28252.867
0.893
Biomarkers for predicting ICU mortality
CRP (mg/L) day 3
1.265
0.798–2.005
0.317
D-dimer (ng/mL) day 1
1.211
0.818–1.793
0.339
Lactate (mg/dL) ratio
0.879
0.005–163.371
0.879
Albumin (g/dL) day 3
1.075
<0.001–7.976
0.261
HMGB1 (pg/mL)
Day 1
1.002
1.000–1.004
0.026
Day 3
0.990
0.968–1.013
0.384
IL8 (pg/mL)
Day 1
1.039
0.955–1.130
0.737
Day 3
1.075
0.940–1.229
0.291
ICU: intensive care unit; APACHE II: Acute Physiology and Chronic Health Evaluation II; SOFA: Sequential Organ Failure Assessment; SAPS II: Simplified Acute Physiology Score II; CRP: C-reactive protein; HMGB1: high-mobility group protein B1; and IL: interleukin.
