Impact of Serum Biomarkers and Clinical Factors on Intensive Care Unit Mortality and 6-Month Outcome in Relatively Healthy Patients with Severe Pneumonia and Acute Respiratory Distress Syndrome
Table 6
Multivariate logistic regression analysis for identification of independent clinical factors and biomarkers of predicting 6-month life dependence.
Variables
Adjusted odds ratio
95% Confidence interval
P
Clinical factors for predicting 6-month life dependence
Age
0.500
0.196~1.277
0.147
Pneumonia type
0.067
0.001~3.803
0.190
Charlson’s comorbidity index
0.046
0.001~1.827
0.101
ICU stay
0.083
0.001~5.067
0.235
Hospital stay
0.861
0.670~1.105
0.240
MV day
1.134
0.851~1.512
0.390
Biomarkers of predicting 6-month life dependence
Lactate (mg/dL)
Day 1
0.909
0.737~1.127
0.385
Day 3
0.944
0.808~1.102
0.465
Albumin (g/dL)
Day 1
18.675
1.018~342.677
0.049
Day 3
0.415
0.016~10.551
0.595
Day 3 : Day 1
0.056
0.000~148.527
0.474
HMGB1 (pg/mL)
Day 1
1.003
0.999~1.006
0.099
Day 3
0.994
0.989~1.000
0.068
ICU: intensive care unit; MV: mechanical ventilation; HMGB1: high-mobility group protein B1.
