Tissue Damage Markers after a Spinal Manipulation in Healthy Subjects: A Preliminary Report of a Randomized Controlled Trial

Table 3

Mean differences between control and both the thoracic and the cervical groups.

		Control-thoracic				Control-cervical
		Mean difference	95% CI	value	Cohen-	Mean difference	95% CI	value	Cohen-
CPK (U/L)	Pretreatment	2.90	(−14.57; 20.37)	1.000	0.19	9.80	(−7.67; 27.27)	0.491	0.61
	Post 0 H	2.00	(−16.81; 20.81)	1.000	0.12	8.90	(−9.91; 27.71)	0.713	0.53
	Post 2 H	3.30	(−16.55; 23.15)	1.000	0.18	6.30	(−13.55; 26.15)	1.000	0.38
LDH (U/L)	Pretreatment	−21.17	(−79.90; 37.55)	1.000	0.38	0.13	(−58.60; 58.85)	1.000	0.00
	Post 0 H	−11.27	(−60.29; 37.75)	1.000	0.23	7.43	(−41.59; 56.45)	1.000	0.20
	Post 2 H	−21.69	(−98.48; 55.11)	1.000	0.37	−34.69	(−111.48; 42.11)	0.777	0.52
Enolase (ng/mL)	Pretreatment	0.39	(−2.26; 3.04)	1.000	0.23	−0.09	(−2.74; 2.56)	1.000	0.04
	Post 0 H	−0.62	(−2.42; 1.17)	1.000	0.47	−0.33	(−2.13; 1.46)	1.000	0.20
	Post 2 H	−0.56	(−5.15; 4.03)	1.000	0.24	−2.71	(−7.30; 1.88)	0.431	0.61
CRP (mg/L)	Pretreatment	0.85	(−0.18; 1.88)	0.136	1.14	−0.07	(−1.10; 0.96)	1.000	0.07
	Post 0 H	1.11	(0.05; 2.18)	0.039	1.49	0.13	(−0.93; 1.20)	1.000	0.12
	Post 2 H	1.03	(−0.09; 2.14)	0.078	1.18	0.06	(−1.06; 1.17)	1.000	0.05
Aldolase (U/L)	Pretreatment	−0.01	(−1.44; 1.43)	1.000	0.00	−0.04	(−1.47; 1.40)	1.000	0.03
	Post 0 H	0.13	(−1.23; 1.49)	1.000	0.10	0.07	(−1.29; 1.43)	1.000	0.06
	Post 2 H	0.33	(−1.32; 1.98)	1.000	0.22	−0.13	(−1.78; 1.52)	1.000	0.09
Myoglobin (ng/mL)	Pretreatment	13.96	(−11.89; 39.80)	0.538	0.59	15.36	(−10.49; 41.20)	0.423	0.58
	Post 0 H	13.88	(−7.57; 35.34)	0.331	0.76	16.38	(−5.07; 37.84)	0.185	0.75
	Post 2 H	33.60	(0.63; 66.57)	0.045^*	1.06	31.10	(−1.87; 64.07)	0.069	0.90

Pre-T: pretreatment values; Post-0 H: values 0 H after intervention; Post-2 H: values 2 H after intervention; CPK: creatine phosphokinase; LDH: lactate dehydrogenase; CRP: C-reactive protein.
Trend to statistical significance.