Haptoglobin 2-2 Genotype Is Associated with TNF-α and IL-6 Levels in Subjects with Obesity

Table 1

Characteristics of the study groups. 𝑛=276.

	HP ^1/HP ^1	HP ^2/HP ^1	HP ^2/HP ^2	P
	𝑛=49	𝑛=87	𝑛=140
Age, years	33.0±11.7	37.1±13.8	36.6±11.6	0.155
Women, n (%)	22 (44.8%)	55 (63.2%)	103 (73.5%)	0.001**
Body mass index, kg/m^2	34.6±3.1	35.0±4.9	35.0±5.1	0.875
Waist circumference, cm	111.6±9.4	109.8±13.4	106.6±11.1	0.01**
Total body fat, %	39.5±6.3	42.1±6.5	42.3±6.4	0.02**
Systolic blood pressure, mmHg	118.4±9.6	120.0±14.6	117.5±12.9	0.360
Diastolic blood pressure, mmHg	75.8±8.4	76.9±10.3	76.0±8.7	0.719
Fasting glucose, mg/dL	104.7±10.6	104.1±14.8	106.0±10.0	0.490
Total cholesterol, mg/dL	182.2±39.9	187.6±33.0	184.9±42.4	0.730
HDL-cholesterol, mg/dL	38.5±13.6	39.9±13.9	38.3±19.4	0.763
LDL-cholesterol, mg/dL	108.6±40.2	111.4±32.9	114.7±47.8	0.244
Triglycerides, mg/dL*	154 (109–205)	163.0 (110–223)	137 (108–197)	0.261
TNF-α, pg/mL*	115.5 (66.5–232.7)	137.8 (91.3–202.2)	174.0 (91.9–298.5)	0.03^**, †
IL-6, pg/mL*	3.4 (1.0–6.5)	2.7 (1.0–8.2)	4.3 (1.0–9.5)	0.08
hsCRP, mg/L*	4.0 (1.8–6.5)	3.8 (1.6–8.4)	3.7 (2.2–8.6)	0.701

Values are mean ± standard deviation.
hsCRP: high-sensitivity C-reactive protein.
P value estimated using one-way ANOVA with post hoc Bonferroni test.
*Median (25–75th percentile), P value estimated using Kruskal-Wallis test.
**Statistical significant difference between HP ¹/HP ¹ and HP ²/HP ².
^†Statistical significant difference between HP ²/HP ¹ and HP ²/HP ².