Disease Markers

Research Article

Haptoglobin 2-2 Genotype Is Associated with TNF-α and IL-6 Levels in Subjects with Obesity

Table 2

Multiple linear regression analysis adjusted by age, sex, waist circumference, and total body fat that evaluates the association between HP ²/HP ² and HP ²/HP ¹ genotypes (independent variables) with TNF-α, IL-6, and C-reactive protein (dependent variables). The HP ¹/HP ¹ was the control group.


	HP ²/HP ² genotype			HP ²/HP ¹ genotype
	β	95% CI	P	β	95% CI	P

Model 1*
TNF-α	0.154	6.26–142.16	0.03	0.026	−32.67–44.47	0.763
IL-6	0.142	0.04–10.69	0.04	0.142	−0.79–9.13	0.099
hsCRP	0.030	−1.25–1.93	0.676	0.044	−1.70–2.88	0.610

Model 2**
TNF-α	0.180	14.41–159.64	0.01	0.048	−28.01–49.57	0.583
IL-6	0.188	1.53–12.72	0.01	0.171	−0.83–10.14	0.054
hsCRP	−0.008	−1.64–1.47	0.914	−0.018	−2.46–1.99	0.834

hsCRP: high-sensitivity C-reactive protein.
*Unadjusted.
**Adjusted by age, sex, waist circumference, and total body fat.