Haptoglobin 2-2 Genotype Is Associated with TNF-α and IL-6 Levels in Subjects with Obesity

Table 3

Characteristics of the HP ²/HP ² genotype according to sex. 𝑛=140.

	HP ^2/HP ^2		P
	Women; 𝑛=103	Men; 𝑛=37
Age, years	37.3±11.3	34.5±12.3	0.229
Body mass index, kg/m^2	35.0±5.5	35.0±3.8	0.992
Waist circumference, cm	103.8±10.2	114.5±9.7	<0.001
Total body fat, %	44.6±4.6	35.8±6.5	<0.001
Systolic blood pressure, mmHg	115.8±13.1	122.0±11.2	0.008
Diastolic blood pressure, mmHg	75.3±8.3	77.8±9.6	0.172
Fasting glucose, mg/dL	106.7±10.2	104.0±9.2	0.148
Total cholesterol, mg/dL	184.3±43.1	186.5±41.0	0.778
HDL-cholesterol, mg/dL	37.2±8.9	41.2±35.0	0.498
LDL-cholesterol, mg/dL	119.0±41.0	102.8±62.2	0.146
Triglycerides, mg/dL*	128 (100–168)	192 (143–252)	<0.001
TNF-α, pg/mL*	156.5 (90.1–301.8)	216.4 (99.9–314.8)	0.502
IL-6, pg/mL*	4.3 (1.0–8.7)	4.8 (1.0–10.8)	0.983
hsCRP, mg/L*	4.2 (2.7–8.9)	2.2 (1.0–8.5)	0.007

Values are mean ± standard deviation.
hsCRP: high-sensitivity C-reactive protein.
*Median (25–75th percentile), P value estimated using Mann-Whitney U test.