Research Article
Characterization of Clinical and Genetic Risk Factors Associated with Dyslipidemia after Kidney Transplantation
Table 3
Association of pharmacokinetics, cytokines, and dyslipidemia-related polymorphisms.
| Number | Gene | Polymorphisms | Categories | OR | 95% CI | |
| 1 | IL-2 | T-330G | G allele | 0.482 | 0.157–1.480 | 0.200 | 2 | IL-2R | C-627T | T allele | 0.591 | 0.187–1.867 | 0.545 | 3 | IL-4 | C-590T | TT genotype | 0.952 | 0.316–2.873 | 0.931 | 4 | IL-10 | A-592C | C allele | 0.912 | 0.299–2.784 | 0.872 | 5 | IL-12B | A1188C | C allele | 1.156 | 0.272–4.905 | 0.861 | 6 | TNF- | G-238A | A allele | — | — | 1.000 | | | G-308A | A allele | — | — | 1.000 | 7 | INF | A874T | T allele | — | — | 1.000 | 8 | TGF-1 | Codon 10 T/C | CC genotype | 1.225 | 0.322–4.667 | 0.964 | | | Codon 25 G/C | C allele | — | — | 1.000 | | | C-509T | TT genotype | 0.719 | 0.203–2.543 | 0.844 | 9 | CRP | T-717C | C allele | 1.474 | 0.268–8.092 | 0.993 | | | G1059C | C allele | 2.289 | 0.349–15.010 | 0.686 | | | C1444T | T allele | 0.926 | 0.228–3.765 | 0.804 | | | C1846T | TT genotype | 1.067 | 0.358–3.182 | 0.908 | 10 | HNF1 | Ileu27Leu | Leu/Leu genotype | 0.857 | 0.318–2.310 | 0.760 | | | Ala98Val | Val allele | — | — | 1.000 | 11 | Adiponectin | T45G | G allele | 2.000 | 0.659–6.066 | 0.341 | | | G276T | T allele | 0.889 | 0.236–3.351 | 0.869 | 12 | PPAR | Val227Ala | Ala allele | — | — | 1.000 | 13 | PPAR | Pro12Ala | Ala allele | 2.000 | 0.115–34.824 | 0.866 | | | C161T | T allele | 2.036 | 0.518–7.995 | 0.565 | 14 | PPAR coactivator1 | Gly482Ser | Ser/ser genotype | 3.250 | 0.480–21.998 | 0.438 | | | G394A | A allele | 0.381 | 0.073–1.992 | 0.449 | 15 | Clock gene | T3111C | C allele | — | — | 0.876 | 16 | ACE | I/D | Deletion | 1.270 | 0.381–4.230 | 0.697 | 17 | ATIIR | A1166C | C allele | 0.454 | 0.105–1.955 | 0.464 | 18 | KCNJ11 | E23K | A allele | 0.571 | 0.185–1.765 | 0.329 | 19 | SUR1 | C-3T | TT genotype | 0.286 | 0.081–1.008 | 0.946 | 20 | UGT1A1 | Promoter TA-repeat | *6 allele | 0.729 | 0.299–1.777 | 0.486 | 21 | UGT1A6*2 | *1/*2 | *2 allele | 0.955 | 0.255–3.576 | 0.789 | 22 | UGT1A7 | Codon 208* 1/*3 | *3 allele | 1.280 | 0.228–7.187 | 0.873 | 23 | UGT1A8*2 | codon173 A/G | GG genotype | 1.176 | 0.507–2.732 | 0.705 | 24 | UGT1A8*3 | codon277 C/Y | Y allele | — | — | 1.000 | | | 25 | UGT1A9 | C-2152T | T allele | — | — | 1.000 | | | T-275A | A allele | — | — | 1.000 | | | C1399T | TT genotype | 1.126 | 0.485–2.617 | 0.783 | 26 | UGT1A9*3 | T98C | C allele | — | — | 1.000 | 27 | UGT2B7 | C802T | T allele | 0.770 | 0.330–1.795 | 0.545 | 28 | CYP2C9*2 | C430T | T allele | — | — | 1.000 | 29 | CYP2C9*3 | A1075C | C allele | 2.741 | 0.715–10.509 | 0.242 | 30 | CYP2C19 | *1/*2/*3 | *2/*2, *2/*3, *3/*3 | 0.697 | 0.220–2.208 | 0.739 | 31 | CYP3A4 | *1/*18 | *18 allele | — | — | 1.000 | | | G20230A | A allele | 0.551 | 0.235–1.294 | 0.169 | 32 | CYP3A5 | A6985G | GG genotype | 1.815 | 0.773–4.263 | 0.169 | 33 | MDR-1 | C1236T | TT genotype | 1.067 | 0.291–3.916 | 0.814 | | | C3435T | T allele | 0.868 | 0.200–3.766 | 0.850 | | | G2677T·A | T or A allele | 0.688 | 0.152–3.102 | 0.922 | 34 | OATP1B1 | A388G | GG genotype | 1.143 | 0.482–2.712 | 0.762 | | | G455A | A allele | — | — | 1.000 | | | T521C | C allele | 0.593 | 0.226–1.551 | 0.284 | | | G721A | A allele | — | — | 1.000 | 35 | OATP1B3 | T334G | GG genotype | 1.176 | 0.507–2.732 | 0.705 | | | G699A | AA genotype | 0.714 | 0.242–2.108 | 0.542 | | | Deletion A | Deletion | 1.309 | 0.310–5.534 | 0.714 | 36 | OATP2B1 | *1/*3 | *3 allele | 0.936 | 0.402–2.176 | 0.877 | 37 | Glucocorticoid receptor | Bcl I C/G | G allele | 3.375 | 1.568–7.266 | 0.001 | | | ER22/23EK | EK allele | — | — | 1.000 | | | N363S | S allele | — | — | 1.000 | 38 | CES2 | rs2303218 | AA genotype | 2.700 | 0.697–10.465 | 0.146 | | | rs3890213 | A allele | 3.429 | 0.791–14.854 | 0.190 |
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IL, interleukin; TNF, tumor necrosis factor; INF, interferon; TGF, transforming growth factor; CRP, C-reactive protein; HNF, hepatocyte nuclear factor; PPAR, peroxisome proliferator-activated receptor; ACE, angiotensin-converting enzyme; ATIIR, angiotensin type 2 receptor; KCNJ, potassium inwardly rectifying channel, subfamily J; SUR, sulfonylurea receptor; UGT, uridine diphosphate-glucuronosyltransferase; CYP, cytochrome P450; MDR, multidrug resistance; OATP, organic anion transporting polypeptide; CES, carboxylesterase; OR, odds ratio; CI, confidence interval.
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