Secernin-1 Contributes to Colon Cancer Progression through Enhancing Matrix Metalloproteinase-2/9 Exocytosis

Table 3

Cox proportional hazards model univariate and multivariate analyses of individual parameters for correlations with overall survival (OS) in 117 patients.

Variable	Univariate	value	Multivariate	value
	HR (95% CI)		HR (95% CI)
Age
<65y	—		NR
≥65y	1.243 (0.607–2.545)	0.551
Gender
Male	—		NR
Female	1.625 (0.792–3.330)	0.185
Location
Right	—
Transverse	0.838 (0.189–3.716)	0.816	NR
Left	0.827 (0.402–1.703)	0.606
T stage
T1 and T2	—		NR
T3 and T4	8.275 (1.129–60.629)	0.038^*
N stage
N0	—
N1	5.927 (2.109–16.654)	0.001^*	NR
N2	25.839 (9.067–73.633)	<0.001^*
M stage
M0	—		NR
M1	42.120 (17.057–104.009)	<0.001^*
AJCC stage
I and II	—		—
III and IV	12.242 (4.277–35.041)	<0.001^*	8.936 (3.049–26.188)	<0.001^*
Differentiation
Well	—		—
Moderate	2.045 (0.804–5.201)	0.133	1.402 (0.544–3.616)	0.484
Poorly	10.417 (4.319–25.125)	<0.001^*	7.419 (2.971–18.524)	<0.001^*
Vessel invasion
No	—		—
Yes	4.355 (1.319–14.382)	0.016^*	1.905 (0.559–6.497)	0.303
SCRN1 expression
Negative and weak	—		—
Moderate and strong	2.849 (1.313–6.184)	0.008^*	2.827 (1.228–6.507)	0.015^*

AJCC: American Joint Committee on Cancer; SCRN1: Secernin-1;
HR: hazard ratio; CI: confidence interval. NR variable was not included in the resultant model.
indicated that the 95% CI of HR was not including 1.
^*means significant difference.