Polymorphisms in the IFNγ, IL-10, and TGFβ Genes May Be Associated with HIV-1 Infection

Table 2

Distribution of allelic and genotypic frequencies in the genes of IFNγ, TNFα, IL-10, IL-6, and TGFβ cytokines in the groups studied.

Genotypes and alleles	HIV-1 (%)	Control (%)		OR
	= 216	= 294		(95% CI)
IFNγ
AA	111 (51.39)	117 (39.79)	0.0336	1.5776	0.0198
AT	89 (41.20)	148 (50.35)		(1.09–2.28)
TT	16 (7.41)	29 (9.86)
A	311 (71)	382 (65)	0.0172	1.3860	0.0210
T	121 (29)	206 (35)		(1.05–1.81)
TNFα
AA	4 (1.86)	6 (2.04)	0.9887	0.9922	0.9416
AG	42 (19.44)	57 (19.39)		(0.25–3.26)
GG	170 (78.70)	231 (78.57)
A	50 (12)	69 (12)	0.9372	0.9845	0.9843
G	382 (88)	519 (88)		(0.66–1.45)
IL-10
AA	123 (56.94)	159 (54.09)	0.7645	1.3261	0.5368
AG	79 (36.58)	111 (37.75)		(0.65–2.67)
GG	14 (6.48)	24 (8.16)
A	325 (75)	429 (73)	0.4139	1.1257	0.4565
G	107 (25)	159 (27)		(0.84–1.49)
IL-6
GG	142 (65.74)	184 (62.59)	0.1856	2.7011	0.1241
GC	70 (32.41)	96 (32.65)		(0.87–8.38)
CC	4 (1.85)	14 (4.76)
G	354 (82)	464 (79)	0.2288	1.2129	0.2621
C	78 (18)	124 (21)		(0.88–1.66)
TGFβ
TT	43 (19.91)	59 (20.07)	0.2136	0.7959	0.4439
TC	97 (44.91)	152 (51.70)		(0.48–1.31)
CC	76 (35.18)	83 (28.23)
T	183 (42)	270 (46)	0.2587	0.8656	0.2864
C	249 (58)	318 (54)		(0.67–1.11)

: analysis between the two groups (Fisher’s exact test or chi-square test). : odds ratio.