Research Article

The Effect of PAI-1 4G/5G Polymorphism and Clinical Factors on Coronary Artery Occlusion in Myocardial Infarction

Table 1

The impact of clinical and genetic factors on coronary artery occlusion after MI.

VariableMI patients with no coronary artery occlusionMI patients with coronary artery occlusionPearson ,

Gender
 Men, (%)49 (59.0)201 (68.6)
 Women, (%)34 (41.0)92 (31.4)
 Total, (%)83 (100.0)293 (100.0)2.656,
Age in years
 Men, mean ± SD60.87 ± 9.4860.37 ± 11.36
 Median (min–max)63 (36–79)61 (31–87)
 Women, mean ± SD65.20 ± 9.7968.27 ± 10.75
 Median (min–max) 66 (42–79)70 (37–86)
 Total, mean ± SD62.65 ± 9.7962.85 ± 11.74
 Median (min–max) 65 (36–79)64 (31–87)
Arterial hypertension
 Men46 (55.4)164 (56.0)4.424,
 Women31 (37.4)83 (28.3)0.027,
 Total77 (92.8)247 (84.3)3.894,
BMI > 30 kg/m2
 Men15 (18.1)63 (21.5)0.010,
 Women10 (12.0)42 (14.3)2.701,
 Total25 (30.1)105 (35.8)0.934,
Diabetes
 Men1 (1.2)24 (8.2)4.290,
 Women4 (4.8)17 (5.8)0.806,
 Total5 (6.0)41 (14.0)3.825,
Dyslipidaemia in anamnesis
 Men40 (48.2)150 (51.2)1.379,
 Women27 (32.5)79 (27.0)0.309,
 Total67 (80.7)229 (78.2)0.630,
PAI-1 genotype distribution according to the patient gender
 Men:
  4G/4G17 (20.4)64 (21.8)2.198,
  4G/5G 20 (24.1)103 (35.1)
  5G/5G12 (14.5)34 (11.6)
 Women:
  4G/4G13 (15.7)28 (9.6)2.736,
  4G/5G 13 (15.7)50 (17.1)
  5G/5G8 (9.6)14 (4.8)
 Total
  4G/4G30 (36.1)92 (31.4)4.607,
  4G/5G 33 (39.8)153 (52.2)
  5G/5G20 (24.1)48 (16.4)
 MAF0.430.42

MAF: minor allele frequency; BMI: body mass index; SD: standard deviation.