Reduced Histone H3 Acetylation in CD4⁺ T Lymphocytes: Potential Mechanism of Latent Autoimmune Diabetes in Adults

Figure 3

The mRNA levels of histone acetyltransferases and deacetylases in CD4⁺ T lymphocytes from patients and controls. (a) Relative mRNA levels of histone acetyltransferases (P300, CREBBP) in CD4⁺ T lymphocytes from patients with LADA () and controls (), as measured by real-time PCR. Levels of target gene mRNA transcripts are normalized to β-actin. The absolute of fold change > 2 was considered significant, LADA patients versus healthy controls. (b) Relative mRNA levels of histone deacetylases (HDAC1, HDAC2, and HDAC7) in CD4⁺ T lymphocytes from patients with LADA () and controls (), the absolute of fold change > 2 was considered significant, LADA patients versus healthy controls.

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