Postoperative CA19-9 Change Is a Useful Predictor of Intrahepatic Cholangiocarcinoma Survival following Liver Resection

Table 4

Risk factors in ICC^‡ patients for overall survival by Cox multivariate analysis.

Factors	Subgroups		HR (95% CI)	value
Age (years)	>65		3.881 (1.301–11.581)	0.01
	≤65		Ref.
PostopCA19-9 (U/mL)	Elevated (>37)	11	4.41 (2.01–6.72)	<0.001
	Normalized (≤37)	63	Ref.
Perineural invasion	(+)	45	3.073 (1.255–7.521)	0.01
	(−)	29	Ref.
Resection margin	≤1 cm	43	3.152 (1.115–8.908)	0.05
	>1 cm	21	Ref.
Lymph node metastasis	(+)	20	3.427 (1.346–8.723)	0.02
	(−)	54	Ref.

ICC^‡: intrahepatic cholangiocarcinoma; postopCA19-9: postoperative lowest CA19-9.