Expression of Ribonucleotide Reductase Subunit-2 and Thymidylate Synthase Correlates with Poor Prognosis in Patients with Resected Stages I–III Non-Small Cell Lung Cancer
Table 3
Patients characteristics, clinicopathologic features, and IHC analysis: association with OS. Results from Kaplan-Meier univariate and Cox multiple regression analyses.
Covariates
5-year survival
Kaplan-Meier
Cox regression
Deaths
SP
%
%
HR
95% CI
value
HR
95% CI
value
Gender
0.967
0.611
Female
20
9
45.0
54.6
1
1
Male
62
28
45.2
54.2
1.12
0.51–2.47
1.28
0.50–3.30
Age at diagnosis
0.850
0.619
≤70 years
46
20
43.5
56.5
1
1
>70 years
36
17
47.2
50.6
1.06
0.55–2.03
1.22
0.56–2.66
Smoking habit
0.066
0.091
Ex/never-smoker
28
9
32.1
67.2
1
1
Current smoker
54
28
51.9
47.7
1.99
0.94–4.24
1.98
0.90–4.39
Pathological TNM
<0.001
<0.001
Stage I
44
12
27.3
71.9
1
1
Stage II
15
9
60.0
40.0
2.81
1.18–6.69
3.51
1.35–9.07
Stage III
23
16
69.7
30.4
4.44
2.08–9.46
6.54
2.86–14.93
Histological type
0.998
0.857
Nonsquamous
54
25
46.3
52.9
1
—
1
Squamous
28
12
42.9
56.9
0.97
0.49–1.93
0.92
0.37–2.31
ERCC1
0.126
0.059
≤140
33
12
26.4
61.4
1
1
>140
49
25
51.0
47.5
1.70
0.85–3.39
2.08
0.97–4.44
BRCA1
0.308
0.750
Negative
36
14
40.9
60.8
1
1
Positive
45
22
60.0
46.7
1.42
0.72–2.77
1.14
0.51–2.54
TS
0.242
0.023
Negative
66
27
40.9
58.8
1
1
Positive
15
9
60.0
40.0
1.56
0.74–3.32
2.93
1.16–7.42
p53R2
0.297
0.699
Negative
57
27
47.4
52.1
1
1
Positive
24
9
37.5
61.9
0.67
0.32–1.43
0.70
0.27–1.83
TUBB3 (median -score)
0.152
0.354
≤60
42
22
52.4
46.8
1
1
>60
40
15
37.5
62.3
0.62
0.32–1.19
0.68
0.30–1.55
RRM1 (median -score)
0.832
0.624
≤120
43
19
44.2
54.7
1
1
>120
38
17
44.7
55.3
1.07
0.56–2.07
0.82
0.36–1.84
RRM2 (median -score)
0.069
0.031
≤140
42
16
35.7
61.9
1
1
>140
39
21
53.8
45.9
1.84
0.95–3.56
2.26
1.08–4.74
SP = cumulative probability of surviving, expression level missing for 1 subject, log-rank (Mantel-Cox) test, test for trend, Cox regression analysis performed on 81 subjects with complete data: HR and 95% CI estimated from the final regression model for covariates retained in the model and from the full model for variables removed, and likelihood ratio test value.
