Expression of Ribonucleotide Reductase Subunit-2 and Thymidylate Synthase Correlates with Poor Prognosis in Patients with Resected Stages I–III Non-Small Cell Lung Cancer
Table 6
Results from the DCC NSCLC microarray subset analyses.
Covariates
5-year survival
Kaplan-Meier
Cox regression
Deaths
SP
%
%
HR
95% CI
value
HR
95% CI
value
Gender
0.036
0.199
Males
174
74
52.7
55.1
1
1
Females
156
47
47.3
66.8
0.68
0.47–0.98
1.25
0.87–1.80
Age at diagnosis
330
121
36.7
0.43
1.03
1.01–1.04
0.008
1.03
1.01–1.05
0.003
Smoking habits
0.224
0.747
Ex/never-smoker
216
71
65.5
63.9
1
1
Current smoker
25
10
7.6
56.2
1.32
0.68–2.57
0.86
0.56–1.33
Unknown
89
40
26.9
53.6
1.39
0.94–2.05
1.09
0.53–2.26
Pathological TNM
0.000
0.000
Stage I
232
60
25.9
71.2
1
1
Stage II
84
49
58.3
39.4
3.19
2.19–4.66
3.32
2.15–4.62
Stage III
14
12
85.7
0.00
6.45
3.43–12.15
5.39
2.84–10.23
ERCC1 (median mRNA expression level)
0.241
0.525
≤−0.045
181
68
37.6
0.60
1
1
>−0.045
149
53
35.6
0.61
0.96
0.67–1.37
1.39
0.96–2.04
BRCA1 (median mRNA expression level)
0.010
0.614
≤0.048
137
40
29.2
0.68
1
1
>0.048
193
81
46.7
0.53
1.64
1.12–2.39
0.95
0.58–1.56
TS (median mRNA expression level)
0.003
0.017
≤−0.018
166
48
38.1
0.67
1
1
>−0.018
164
73
44.5
0.59
1.78
1.24–2.56
1.57
1.08–2.28
TUBB3 (median mRNA expression level)
0.395
0.890
≤−0.116
189
63
33.3
0.63
1
1
>−0.116
141
58
41.1
0.57
1.17
0.82–1.67
1.21
0.82–1.78
RRM1 (median mRNA expression level)
0.130
0.419
≤−0.130
194
65
33.5
0.63
1
1
>−0.130
136
56
41.2
0.57
1.32
0.92–1.89
0.88
0.59–1.32
RRM2 (median mRNA expression level)
0.005
0.757
≤0.213
155
46
29.7
0.67
1
1
>0.213
175
75
42.9
0.55
1.69
1.17–2.44
1.06
0.59–1.88
SP = cumulative probability of surviving, log-rank (Mantel-Cox) test, test for trend, HR and 95% CI from the final regression model for covariates retained in the model and from the full model for variables removed, and likelihood ratio test value.
