MicroRNA-155 Hallmarks Promising Accuracy for the Diagnosis of Various Carcinomas: Results from a Meta-Analysis

Table 3

Summary table of the diagnostic accuracy of miR-155 for various cancers.

Analyses	Sensitivity; (95% CI)	Specificity; (95% CI)	DOR; (95% CI)	Positive LR; (95% CI)	Negative LR; (95% CI)	AUC (95% CI)
MicroRNA profile
Single miR-155	0.82 (0.73–0.88)	0.77 (0.70–0.83)	15.34 (7.32–32.17)	3.56 (2.55–4.95)	0.23 (0.14–0.37)	0.85
Paneled miR-155	0.76 (0.68–0.82)	0.82 (0.77–0.86)	14.27 (7.98–25.53)	4.23 (3.12–5.75)	0.30 (0.22–0.40)	0.86
Sample types
Plasma-based	0.74 (0.58–0.71)	0.70 (0.63–0.76)	5.54 (2.79–11.03)	2.02 (1.65–2.48)	0.41 (0.27–0.63)	0.73
Serum-based	0.78 (0.74–0.82)	0.77 (0.71–0.82)	15.61 (7.03–34.67)	3.47 (2.40–5.02)	0.23 (0.13–0.41)	0.87
Ethnicity
Asian	0.72 (0.68–0.76)	0.72 (0.68–0.76)	8.03 (4.82–13.38)	2.68 (2.07–3.46)	0.38 (0.29–0.50)	0.81
Caucasian	0.94 (0.89–0.97)	0.79 (0.69–0.87)	61.93 (23.00–166.75)	5.79 (1.51–22.24)	0.08 (0.04–0.15)	0.96
Overall	0.79 (0.73–0.84)	0.79 (0.75–0.84)	14.62 (9.10–23.48)	3.86 (3.05–4.90)	0.26 (0.20–0.35)	0.86
Outliers excluded	0.84 (0.74–0.90)	0.76 (0.68–0.83)	16.41 (3.32–36.77)	3.54 (2.49–5.05)	0.21 (0.13–0.36)	0.86

CI: confidence interval; LR: likelihood ratio; DOR: diagnostic odds ratio; AUC: area under the curve.