Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction?

Table 1

Correlations of new biomarkers with surrogates of left ventricular filling pressure.

Reference		Biomarker	Surrogates of LVFP
				PCWP	LVEDP
Celik et al. [44]	57	CT-1	0.307^*			0.003
Kapur et al. [45]	82	sEng			0.689^*	<0.0001
Bartunek et al. [48]	121	ST2			0.37^*	<0.01
Santhanakrishnan et al. [50]	151	ST2	0.256^*			0.002
		GDF-15	0.406^*			<0.001
		hsTnT	0.424^*			<0.001
Shah et al. [56]	115	Galectin-3	0.35^*			0.01
Andersen et al. [57]	74	Galectin-3		NNI		NS

CT-1: cardiotrophin-1; : early diastolic transmitral flow velocity; : early diastolic velocity of mitral annular motion; GDF-15: growth differentiation factor 15; hsTnT: high-sensitivity troponin T; LVEDP: left ventricular end-diastolic pressure; LVFP: left ventricular filling pressure; PCWP: pulmonary capillary wedge pressure; sEng: soluble endoglin; NNI: number not included in the paper; NS: not significant; ^*correlation coefficients are included.