Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction?

Table 2

Responses of BNP levels to exercise in healthy volunteers, patients with hypertension, and in subjects with hypertension and suspected or proven HFpEF.

Reference		Diagnosis	Biomarker	Plasma levels
				Rest	Exercise
Huang et al. [60]	23	Healthy cont.	BNP (pg/mL)	3.38 ± 0.50^*	8.21 ± 2.02^*	<0.01
Kohno et al. [61]	6	Hypertension	BNP (pg/mL)^**	14.8 ± 4.1^**	40.9 ± 6.5^**	<0.01
Mottram et al. [62]	26	Hypertension + HFpEF sp	BNP (pg/mL)	48 ± 57	74 ± 97	<0.001
					123 ± 124^***

Results are presented as mean ± SD unless otherwise stated. Cont.: controls; sp: suspected or proven; ^*mean ± SEM; ^**pulmonary arterial BNP levels; ^***in a subgroup of patients with elevated left ventricular filling pressure.