The -844 G>A PAI-1 Polymorphism Is Associated with Acute Coronary Syndrome in Mexican Population

Table 3

Clinical and demographic characteristics in the ACS patients related to -844 G>A polymorphism of PAI-1 gene by genetic models.

	ACS ()	Genotype							Dominant				Recessive
		GG^a ()	GA ()	OR (CI)		AA ()	OR (CI)		GG^a ()	GA + AA ()	OR (CI)		GG + GA^a ()	AA (42)	OR (CI)
F/M	66/230	30/91	24/109	—	—	12/30	—	—	—	—	—	—	—	—	—	—
UA^b	31	14	14	—	—	3	—	—	14	17	—	—	28	3	—	—
NSTEMI	40	12	18	1.06; (0.48–2.34)	0.88	10	1.43; (0.38–5.30)	0.59	12	28	1.13; (0.53–2.39)	0.76	30	10	1.38; (0.39–4.83)	0.61
STEMI	225	95	101	1.50; (0.53–4.25)	0.44	29	3.89; (0.87–17.48)	0.07	95	130	1.92; (0.72–5.11)	0.19	196	29	3.11; (0.78–12.48)	0.09
OB^c	116	47	49	0.92; (0.55–1.53)	0.74	20	1.43; (0.71–2.90)	0.32	47	69	1.03; (0.64–1.65)	0.92	96	20	1.49; (0.78–2.89)	0.23
DM2^c	143	65	60	0.71; (0.43–1.16)	0.17	18	0.65; (0.32–1.31)	0.23	65	78	0.69; (0.44–1.10)	0.12	125	18	0.77; (0.40–1.49)	0.45
HBP^c	179	77	76	0.76; (0.46–1.26)	0.29	26	0.93; (0.45–1.92)	0.84	77	102	0.79; (0.49–1.29)	0.35	153	26	1.07; (0.55–2.10)	0.84
DYS^c	126	52	50	0.79; (0.48–1.32)	0.38	24	1.77; (0.87–3.59)	0.11	52	74	0.97; (0.61–1.55)	0.91	102	24	1.99; (1.03–3.85)	0.04

ACS: acute coronary syndrome; DM2: type 2 diabetes mellitus; DYS: dyslipidemia; F: female; HBP: high blood pressure; M: male; NSTEMI: non-ST elevation myocardial infarction; OB: obesity/overweight; SMO: smoking; STEMI: ST elevation myocardial infarction; UA: unstable angina. ^aReference genotype. ^bUA used as reference with ACS types. ^cNot present as reference variable. Significant value.