Research Article
The -844 G>A PAI-1 Polymorphism Is Associated with Acute Coronary Syndrome in Mexican Population
Table 3
Clinical and demographic characteristics in the ACS patients related to -844 G>A polymorphism of PAI-1 gene by genetic models.
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ACS () | Genotype | Dominant | Recessive | GGa () | GA () | OR (CI) | | AA () | OR (CI) | | GGa () | GA + AA () | OR (CI) | | GG + GAa () | AA (42) | OR (CI) | |
| F/M | 66/230 | 30/91 | 24/109 | — | — | 12/30 | — | — | — | — | — | — | — | — | — | — | UAb | 31 | 14 | 14 | — | — | 3 | — | — | 14 | 17 | — | — | 28 | 3 | — | — | NSTEMI | 40 | 12 | 18 | 1.06 (0.48–2.34) | 0.88 | 10 | 1.43 (0.38–5.30) | 0.59 | 12 | 28 | 1.13 (0.53–2.39) | 0.76 | 30 | 10 | 1.38 (0.39–4.83) | 0.61 | STEMI | 225 | 95 | 101 | 1.50 (0.53–4.25) | 0.44 | 29 | 3.89 (0.87–17.48) | 0.07 | 95 | 130 | 1.92 (0.72–5.11) | 0.19 | 196 | 29 | 3.11 (0.78–12.48) | 0.09 | OBc | 116 | 47 | 49 | 0.92 (0.55–1.53) | 0.74 | 20 | 1.43 (0.71–2.90) | 0.32 | 47 | 69 | 1.03 (0.64–1.65) | 0.92 | 96 | 20 | 1.49 (0.78–2.89) | 0.23 | DM2c | 143 | 65 | 60 | 0.71 (0.43–1.16) | 0.17 | 18 | 0.65 (0.32–1.31) | 0.23 | 65 | 78 | 0.69 (0.44–1.10) | 0.12 | 125 | 18 | 0.77 (0.40–1.49) | 0.45 | HBPc | 179 | 77 | 76 | 0.76 (0.46–1.26) | 0.29 | 26 | 0.93 (0.45–1.92) | 0.84 | 77 | 102 | 0.79 (0.49–1.29) | 0.35 | 153 | 26 | 1.07 (0.55–2.10) | 0.84 | DYSc | 126 | 52 | 50 | 0.79 (0.48–1.32) | 0.38 | 24 | 1.77 (0.87–3.59) | 0.11 | 52 | 74 | 0.97 (0.61–1.55) | 0.91 | 102 | 24 | 1.99 (1.03–3.85) | 0.04 |
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ACS: acute coronary syndrome; DM2: type 2 diabetes mellitus; DYS: dyslipidemia; F: female; HBP: high blood pressure; M: male; NSTEMI: non-ST elevation myocardial infarction; OB: obesity/overweight; SMO: smoking; STEMI: ST elevation myocardial infarction; UA: unstable angina. aReference genotype. bUA used as reference with ACS types. cNot present as reference variable. Significant value.
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