Association between Plasma Fibrinogen Levels and Mortality in Acute-on-Chronic Hepatitis B Liver Failure
Table 2
Clinical characteristics of the AoCLF patients according to the plasma fibrinogen tertiles.
Variables
Group 1 (52)
Group 2 (62)
Group 3 (55)
P value
Fibrinogen (g/L)
<1.10
1.10~1.50
>1.50
Female/male
21/31#*
9/53☆
2/53
<0.001
Age (year)
49.42 ± 12.51*
46.15 ± 13.26
42.84 ± 12.90
0.030
TBIL (μmol/L)
352 (40–826)#*
223 (42–947)
117 (10–804)
<0.001
ALT (U/L)
81 (10–3686)
61 (15–2401)
55 (20–1500)
0.299
ALB (g/L)
31.6 (20.4–46.2)
32.3 (24.3–44.7)
32.8 (23.4–46.1)
0.112
Cr (μmol/L)
65 (24–263)
66 (23–760)
66 (28–273)
0.650
PT (S)
28.2 (14.2–120)#*
22.8 (14.1–43.1)☆
17.2 (11.1–29.7)
<0.001
INR
2.41 (1.23–10.40)#*
1.96 (1.22–3.60)☆
1.49 (0.97–2.51)
<0.001
D-dimer (μg/L FEU)
3090 (380–6990)#*
1715 (150–43858)
1070 (150–7080)
<0.001
MELD score
24.58 (11.27–57.17)#*
19.56 (5.2–50.07)☆
15.74 (3.98–39.04)
<0.001
Decompensation (yes/no)
35/17#*
30/32
23/32
0.024
Mortality (yes/no)
28/24#*
20/42
12/43
0.002
AoCLF, acute-on-chronic hepatitis B liver failure; TBIL, total bilirubin; ALT, alanine aminotransferase; ALB, albumin; Cr, creatinine; PT, prothrombin time; INR, international normalized ratio; MELD score, the model for end-stage liver disease score. value: comparison among the three groups. #P < 0.05, group 1 versus group 2. *P < 0.05, group 1 versus group 3. ☆P < 0.05, group 2 versus group 3.
