High Serum Level of β2-Microglobulin in Late Posttransplant Period Predicts Subsequent Decline in Kidney Allograft Function: A Preliminary Study
Table 1
Baseline characteristics of the study population.
Parameter
Satisfactory Function subset
Dysfunction subset
value
Recipient age at baseline, years
37 ± 12
40 ± 11
0.329
Recipient gender, (%)
0.573
Male
21 (54)‡
19 (48)
Female
18 (46)
21 (52)
CNI, (%)
0.105
CsA
34 (87)
29 (73)
Tacrolimus
5 (13)
11 (27)
Antiproliferative agent, (%)
0.190
Azathioprine
3 (8)
7 (18)
Mycophenolate mofetil
36 (92)
33 (72)
Type of donor, (%)
0.958
Deceased
32 (82)
33 (83)
Living related
7 (18)
7 (17)
Impaired initial function, (%)
2 (5.1)
10 (25)
0.014
Previous acute rejection, (%)
5 (12.8)
14 (35)
0.021
Time after transplantation (months)
72.6 ± 46.9
98.2 ± 57.7
0.034
Serum creatinine (µmol/L)
117.7 ± 29.5
195.7 ± 49.7
<0.001
eGFR at baseline (mL/min/1.73 m2)
66.7 ± 13.4
34.3 ± 7.9
<0.001
Serum urea (mmol/L)
7.4 ± 2.3
11.9 ± 3.4
<0.001
Proteinuria/creatinine (mg/mmol)
3.6 (2.7–7.9)†
11.8 (4.5–21.8)
<0.001
Proteinuria/creatinine > 15 mg/mmol, (%)
2 (5.1)
15 (37.5)
<0.001
Diuresis (mL/day)
1428 ± 243
1498 ± 372
0.331
Urine specific gravity
1012 ± 4
1007 ± 4
<0.001
Mean arterial pressure at baseline (mm Hg)
103 ± 9
113 ± 9
<0.001
Treated hypertension at baseline, (%)
12 (30.8)
28 (70.0)
<0.001
CNI: calcineurin inhibitors; CsA: cyclosporine A; eGFR: estimated glomerular filtration rate; : number of patients investigated; mean ± standard deviation, Student’s -test used for comparison; †median (interquartile range), Mann-Whitney’s -test used for comparison; ‡numbers (percentages), Chi-square tests used for comparison.
