High Serum Level of β2-Microglobulin in Late Posttransplant Period Predicts Subsequent Decline in Kidney Allograft Function: A Preliminary Study

Table 4

AUC for potential markers of eGFR decline by ≥25% after one and two years of follow-up.

Predictive variables	AUC	CI	-level
eGFR decline by 25% after 1 year of follow-up,
Proteinuria/creatinine	0.724	0.606–0.823	0.056
Previous acute rejection	0.675	0.559–0.777	0.055
Serum β2MG	0.724	0.612–0.819	0.026
Proteinuria/creatinine + previous acute rejection + serum β2MG	0.910	0.818–0.965	<0.001
eGFR decline by 25% after 2 years of follow-up,
Serum β2MG	0.668	0.553–0.770	0.047
Time after transplantation	0.712	0.599–0.808	0.008
Serum β2MG + time after transplantation	0.821	0.719–0.899	<0.001

β2MG: β2-microglobulin; eGFR: estimated glomerular filtration rate; AUC: areas under the receiver operating characteristic curve; CI: 95% confidence interval; : number of patients with certain decline in eGFR; only variables that significantly influenced the eGFR decline in univariate logistic regression are included.