Carboxyhemoglobin Formation in Preterm Infants Is Related to the Subsequent Development of Bronchopulmonary Dysplasia

Table 2

Cutoff values for carboxyhemoglobin and the urinary oxidative stress markers for predicting the development of moderate-to-severe bronchopulmonary dysplasia.

Parameter	Cutoff value	Sensitivity	Specificity	PPV	NPV	AUC
CO-Hb	1.0%	88.9%	75.0%	66.7%	92.3%	0.882
Urinary 8-OHdG	13.4 ng/mg Cr	88.9%	58.7%	61.5%	87.5%	0.778
Urinary AOPP	0.43 mol/mg Cr	77.8%	75.0%	70.0%	81.8%	0.750
Urinary HEL	0.17 nmol/mg Cr	62.5%	87.5%	83.3%	70.0%	0.773

AOPP: advanced oxidation protein products, AUC: area under the curve, CO-Hb: carboxyhemoglobin, Cr: creatinine, HEL: N-(hexanoyl) lysine, NPV: negative predictive value, 8-OHdG: 8-hydroxydeoxyguanosine, and PPV: positive predictive value.