Detection of SNCA and FBN1 Methylation in the Stool as a Biomarker for Colorectal Cancer

Table 2

The positive rate of hypermethylated SNCA and FBN1 in tissue and stool samples.

Parameters	SNCA methylation		Positive percent	value	FBN1 methylation		Positive percent	value
	Positive	Negative			Positive	Negative
Tissue samples
CRC	64	25	71.9%	<0.001^*	69	20	77.5%	<0.001^*
Normal	1	88	1.1%		3	89	3.4%
Stool samples
CRC	62	27	70%	<0.001^*	63	26	70.8%	<0.001^*
Normal	0	30	0%		2	28	6.7%
Stool samples (Dukes A stage)
SNCA methylation	11	6	64.7%	0.039^*	13	4	76.5%	0.006^*
FOBT	5	12	29.4%		5	12	29.4%

Using chi-square for this statistic.
^*Statistically significant.