Detection of SNCA and FBN1 Methylation in the Stool as a Biomarker for Colorectal Cancer

Table 4

Correlation between SNCA and FBN1 hypermethylation status in stool DNA of CRC patients and clinicopathological parameters.

Parameters	Number of cases	SNCA		FBN1
		Methylation	value	Methylation	value
Age
<50	24	17 (70.8%)	0.958^a	19 (79.2%)	0.173^a
50–60	24	18 (75.0%)		17 (70.8%)
60–70	22	15 (68.2%)		15 (68.2%)
>70	19	14 (73.7%)		18 (94.7%)
Gender
Male	54	38 (70.4%)	0.688^a	41 (75.9%)	0.653^a
Female	35	26 (74.3%)		28 (80.0%)
Tumor location
Left hemicolon	19	13 (68.4%)	0.470^a	17 (89.5%)	0.255^a
Transverse colon	5	4 (80.0%)		5 (100%)
Right hemicolon	8	4 (50.0%)		6 (75.0%)
Rectum	57	43 (75.4%)		41 (71.9%)
Pathological pattern
Ulcerative type	60	42 (70.0%)	0.581^a	46 (76.7%)	0.504^a
Protrude type	24	19 (79.2%)		20 (83.3%)
Infiltrating type	5	3 (60.0%)		3 (60.0%)
Dukes’ stage
A	17	11 (64.7%)	0.323^a	13 (76.5%)	0.237^a
B	36	29 (80.6%)		25 (69.4%)
C	36	24 (66.7%)		31 (94.4%)

Using chi-square for this statistic.