Single Nucleotide Polymorphisms in P2X7 Gene Are Associated with Serum Immunoglobulin G Responses to Mycobacterium tuberculosis in Tuberculosis Patients
Table 2
Genotype frequency distributions of 1513A>C and -762T>C in P2X7 gene.
Genotype
Control group ()
Case group ()
OR
95% CI
1513A>C
AA
51 (58.6%)
33 (32.0%)
Ref.
AC
27 (31.0%)
49 (47.6%)
0.002
2.805
1.475–5.332
CC
9 (10.4 %)
21 (20.4%)
0.004
3.606
1.473–8.829
Dominant model
AA
51 (58.6%)
33 (32.0%)
Ref.
AC + CC
36 (41.4%)
70 (67.6%)
<0.001
3.005
1.658–5.446
Recessive model
AA + AC
78 (89.6%)
82 (79.6%)
Ref.
CC
9 (10.4%)
21 (20.4%)
0.06
2.22
0.958–5.143
Allele
A
129 (74.1%)
115 (55.8%)
Ref.
C
45 (25.9%)
91 (44.2%)
<0.001
2.268
1.466–3.511
-762T>C
TT
48 (55.2%)
21 (20.4%)
Ref.
TC
30 (34.5%)
47 (45.6%)
<0.001
3.581
1.800–7.123
CC
9 (10.3%)
35 (34.0%)
<0.001
8.889
3.634–21.74
Dominant model
TT
48 (55.2%)
21 (20.4%)
Ref.
CC + TC
39 (44.8%)
82 (79.6%)
<0.001
4.932
2.598–9.365
Recessive model
TT + TC
78 (89.7%)
68 (66.0%)
Ref.
CC
9 (10.3%)
35 (34.0%)
<0.001
4.461
2.001–9.944
Allele
T
126 (72.4%)
89 (43.3%)
Ref.
C
48 (27.6%)
117 (56.8%)
<0.001
3.451
2.240–5.315
OR: odds ratio; CI: confidence interval; Ref.: reference.
