Disease Markers

Research Article

Assessment of Immunological Biomarkers in the First Year after Heart Transplantation

Table 3

Mean, standard deviations, and values of the different immunological parameters CD25, CD95, IL2, IFN, plasmacytoid and myeloid dendritic cells, IP10, and MIG in recipients with and without acute cellular rejection at three different time points during the first year after heart transplantation. values refer to the comparison of the two groups: recipients with acute cellular rejections and recipients without acute cellular rejections.


	1st quarter		2nd quarter		2nd half year
	Mean ± SD	value	Mean ± SD	value	Mean ± SD	value

CD25
Without ACR	34.9% ± 20.7%	0.287	33.5% ± 21.0%	0.392	31.4% ± 20.1%	0.592
With ACR	22.7% ± 26.9%	0.287	44.1% ± 27.6%	0.392	37.2% ± 27.1%	0.592
CD95
Without ACR	42.2% ± 23.2%	0.033	43.6% ± 27.3%	0.288	42.8% ± 28.5%	0.510
With ACR	15.1% ± 19.2%	0.033	59.6% ± 23.8%	0.288	52.5% ± 29.4%	0.510
IL-2
Without ACR	9.9% ± 12.2%	0.537	15.2% ± 13.1%	0.150	18.0% ± 15.0%	0.130
With ACR	5.9% ± 9.1%	0.537	27.5% ± 16.6%	0.150	30.9% ± 16.9%	0.130
IFN
Without ACR	10.1% ± 11.1%	0.461	16.9% ± 12.2%	0.201	24.9% ± 21.5%	0.501
With ACR	19.3% ± 21.9%	0.461	27.2% ± 17.6%	0.201	33.2% ± 26.3%	0.501
pDCs
Without ACR	18.8% ± 12.4%	0.797	26.2% ± 11.4%	0.404	31.5% ± 12.3%	0.443
With ACR	17.1% ± 14.9%	0.797	32.0% ± 7.3%	0.404	36.6% ± 7.9%	0.443
mDCs
Without ACR	39.6% ± 20.2%	0.465	49.1% ± 15.9%	0.847	48.7% ± 21.8%	0.519
With ACR	48.2% ± 30.9%	0.465	51.0% ± 11.2%	0.847	40.5% ± 17.4%	0.519
pDC/mDC ratio
Without ACR	0.8 ± 1.3	0.702	0.7 ± 0.8	0.922	1.1 ± 1.3	0.915
With ACR	0.5 ± 0.4	0.702	0.7 ± 0.3	0.922	1.2 ± 0.8	0.915
IP10
Without ACR	36.5 pg/mL ± 33.4 pg/mL	0.289	29.9 pg/mL ± 21.6 pg/mL	0.017	39.8 pg/mL ± 38.7 pg/mL	0.511
With ACR	57.7 pg/mL ± 59.9 pg/mL	0.289	67.5 pg/mL ± 33.7 pg/mL	0.017	54.0 pg/mL ± 58.3 pg/mL	0.511
MIG
Without ACR	33.5 pg/mL ± 41.6 pg/mL	0.418	22.7 pg/mL ± 17.6 pg/mL	0.783	25.5 pg/mL ± 14.4 pg/mL	0.891
With ACR	16.1 pg/mL ± 7.8 pg/mL	0.418	26.3 pg/mL ± 11.8 pg/mL	0.783	24.5 pg/mL ± 12.0 pg/mL	0.891

ACR, acute cellular rejection; CD25, alpha chain of the interleukin-2 receptor; CD95, Fas receptor; IFN, interferon g; IL-2, interleukin-2; IP10, CXC chemokine ligand 10; mDCs, myeloid dendritic cells; MIG, CXC chemokine ligand 9; pDCs, plasmacytoid dendritic cells; SD, standard deviation.